Anti-P4HA2 Antibody Picoband® APC Conjugated

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.

P4HA2; UNQ290/PRO330; Prolyl 4-hydroxylase subunit alpha-2; 4-PH alpha-2; EC 1.14.11.2; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2

1. Annunen, P., Helaakoski, T., Myllyharju, J., Veijola, J., Pihlajaniemi, T., Kivirikko, K. I. Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha (II) and characterization of the type II enzyme tetramer: the alpha (I) and alpha (II) subunits do not form a mixed alpha (I) alpha (II) beta2 tetramer. J. Biol. Chem. 272: 17342-17348, 1997. 2. Aro, E., Salo, A. M., Khatri, R., Finnila, M., Miinalainen, I., Sormunen, R., Pakkanen, O., Holster, T., Soininen, R., Prein, C., Clausen-Schaumann, H., Aszodi, A., Tuukkanen, J., Kivirikko, K. I., Schipani, E., Myllyharju, J. Severe extracellular matrix abnormalities and chondrodysplasia in mice lacking collagen prolyl 4-hydroxylase isoenzyme II in combination with a reduced amount of isoenzyme I. J. Biol. Chem. 290: 16964-16978, 2015. 3. Frazer, K. A., Ueda, Y., Zhu, Y., Gifford, V. R., Garofalo, M. R., Mohandas, N., Martin, C. H., Palazzolo, M. J., Cheng, J.-F., Rubin, E. M. Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region. Genome Res. 7: 495-512, 1997.