Anti-CLTA Antibody Picoband® APC Conjugated

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12.

A synthetic peptide corresponding to a sequence at the C-terminus of human CLTA. Human CLTA shares 100% amino acid (aa) sequence identity with mouse CLTA.

1. Brodsky, F. M., Galloway, C. J., Blank, G. S., Jackson, A. P., Seow, H.-F., Drickamer, K., Parham, P. Localization of clathrin light-chain sequences mediating heavy-chain binding and coated vesicle diversity. Nature 326: 203-205, 1987. 2. Deborde, S., Perret, E., Gravotta, D., Deora, A., Salvarezza, S., Schreiner, R., Rodriguez-Boulan, E. Clathrin is a key regulator of basolateral polarity. Nature 452: 719-723, 2008. 3. Gross, M. B. Personal Communication. Baltimore, Md. 2/2/2011.