Anti-PADI2 Antibody Picoband®

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.

PADI2; KIAA0994; PAD2; PDI2; Protein-arginine deiminase type-2; EC 3.5.3.15; PAD-H19; Peptidylarginine deiminase II; Protein-arginine deiminase type II

E.coli-derived human PADI2 recombinant protein (Position: Q38-K640) . Human PADI2 shares 92.7% and 93.2% amino acid (aa) sequence identity with mouse and rat PADI2, respectively.

1. Ishigami, A., Ohsawa, T., Asaga, H., Akiyama, K., Kuramoto, M., Maruyama, N. Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin. Arch. Biochem. Biophys. 407: 25-31, 2002. 2. Suzuki, A., Yamada, R., Chang, X., Tokuhiro, S., Sawada, T., Suzuki, M., Nagasaki, M., Nakayama-Hamada, M., Kawaida, R., Ono, M., Ohtsuki, M., Furukawa, H., and 13 others. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nature Genet. 34: 395-402, 2003. 3. Watanabe, K., Senshu, T. Isolation and characterization of cDNA clones encoding rat skeletal muscle peptidylarginine deiminase. J. Biol. Chem. 264: 15255-15260, 1989.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.