Anti-YTHDF1 Antibody Picoband® APC Conjugated
Product Specifications
Background
Enables N6-methyladenosine-containing RNA reader activity and ribosome binding activity. Involved in mRNA destabilization; positive regulation of translational initiation; and stress granule assembly. Located in P-body and cytoplasmic stress granule. Implicated in colorectal cancer.
Synonyms
YTHDF1; C20orf21; YTH domain-containing family protein 1; Dermatomyositis associated with cancer putative autoantigen 1; DACA-1
Gene Name
YTHDF1
Gene ID
54915
UniProt
Q9BYJ9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human YTHDF1. Human YTHDF1 shares 95.2% amino acid (aa) sequence identity with mouse YTHDF1.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Han, D., Liu, J., Chen, C., Dong, L., Liu, Y., Chang, R., Huang, X., Liu, Y., Wang, J., Dougherty, U., Bissonnette, M. B., Shen, B., Weichselbaum, R. R., Xu, MM., He, C. Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells. Nature 566: 270-274, 2019. Note: Erratum: Nature 568: E3, 2019. Electronic Article. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 8/19/2015. 3. Li, A., Chen, Y.-S., Ping, X.-L., Yang, X., Xiao, W., Yang, Y., Sun, H.-Y., Zhu, Q., Baidya, P., Wang, X., Bhattarai, D. P., Zhao, Y.-L., Sun, B.-F., Yang, Y.-G. Cytoplasmic m6A reader YTHDF3 promotes mRNA translation. (Letter) Cell Res. 27: 444-447, 2017.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A09853-2-APC
Calculated Molecular Weight
61 kDa
Applications Notes
6
Gene Name Synonym
YTH N6-methyladenosine RNA binding protein F1
Protein Name
YTH domain-containing family protein 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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