Anti-YTHDF1 Antibody Picoband®

Enables N6-methyladenosine-containing RNA reader activity and ribosome binding activity. Involved in mRNA destabilization; positive regulation of translational initiation; and stress granule assembly. Located in P-body and cytoplasmic stress granule. Implicated in colorectal cancer.

A synthetic peptide corresponding to a sequence at the C-terminus of human YTHDF1. Human YTHDF1 shares 95.2% amino acid (aa) sequence identity with mouse YTHDF1.

1. Han, D., Liu, J., Chen, C., Dong, L., Liu, Y., Chang, R., Huang, X., Liu, Y., Wang, J., Dougherty, U., Bissonnette, M. B., Shen, B., Weichselbaum, R. R., Xu, MM., He, C. Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells. Nature 566: 270-274, 2019. Note: Erratum: Nature 568: E3, 2019. Electronic Article. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 8/19/2015. 3. Li, A., Chen, Y.-S., Ping, X.-L., Yang, X., Xiao, W., Yang, Y., Sun, H.-Y., Zhu, Q., Baidya, P., Wang, X., Bhattarai, D. P., Zhao, Y.-L., Sun, B.-F., Yang, Y.-G. Cytoplasmic m6A reader YTHDF3 promotes mRNA translation. (Letter) Cell Res. 27: 444-447, 2017.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.