TDP1 Inhibitor-2
Product Specifications
UNSPSC Description
TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC50 of 3.5 μM[1].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tdp1-inhibitor-2.html
Solubility
DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
ClC1=CC=CC(Cl)=C1COC2=CC=C(C(C3=CC(C=CC=C4)=C4OC3=O)=CC(O5)=O)C5=C2
Molecular Weight
465.28
References & Citations
[1]Mamontova EM, et al. Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. Bioorg Med Chem. 2020 Jan 1;28(1):115234.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147750/TDP1-Inhibitor-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147750/TDP1-Inhibitor-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
859142-95-3
Available Sizes
Curated Selection
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