Anti-PGD Rabbit Monoclonal Antibody

Boster Bio Anti-PGD Rabbit Monoclonal Antibody catalog # M01623-1. Tested in WB, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

E3 ubiquitin-protein ligase RAD18;6.3.2.-; Postreplication repair protein RAD18; hHR18; hRAD18; RING finger protein 73; RAD18; RNF73

Gene Name

PGD

Gene ID

5226

UniProt

P52209

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from PGD

Clonality

Monoclonal

Clone

Clone: 26P73

Tissue Specificity

Expressed ubiquitously in normal tissues.

Applications

WB, ICC, IF, IP, Flow Cytometry

Field of Research

Cell Biology,2339, DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ring Finger E3 Ligase, Ubiquitin E3 Enzymes

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono- ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

56223 MW

Observed Molecular Weight

43 kDa

Gene Name Synonym

E3 ubiquitin-protein ligase RAD18

Subcellular Location

Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with chromatin (PubMed:25931565) . Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077) . Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607) . Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565) . .

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

F2165 96 Tests

N (G) N (G) -dimethylarginine dimethylaminohydrolase 2 (DDAH2) Human ELISA Kit

Ask

View Details

PVT47934 2 µg

pLV3-CMV-BAG6-3×FLAG-CopGFP-Puro Plasmid

Ask