Anti-Caspase-1 + p10 + p12 Rabbit Monoclonal Antibody
Boster Bio Anti-Caspase-1 + p10 + p12 Rabbit Monoclonal Antibody catalog # M00048-2. Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Caspase-1; CASP-1;3.4.22.36; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45; Caspase-1 subunit p20; Caspase-1 subunit p10; CASP1; IL1BC, IL1BCE
Gene Name
CASP1
Gene ID
834
UniProt
P29466
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from Caspase-1 + p10 + p12
Clonality
Monoclonal
Clone
Clone: 26C50
Tissue Specificity
Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. .
Applications
WB, IP
Field of Research
Apoptosis, Caspases, Cell Biology, Intracellular
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs) . Can also promote apoptosis. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
45159 MW
Observed Molecular Weight
45 kDa, 42 kDa, 35 kDa, 12 kDa, 10 kDa
Gene Name Synonym
Caspase-1
Subcellular Location
Cytoplasm.
Protein Name
P2X purinoceptor 1
Isotype
IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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