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Anti-IL12 p40 Rabbit Monoclonal Antibody

Boster Bio Anti-IL12 p40 Rabbit Monoclonal Antibody catalog # M01152-2. Tested in WB application. This antibody reacts with Human.

Product Specifications

Synonyms

NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3; NFKBIA; IKBA, MAD3, NFKBI

Gene Name

IL12B

Gene ID

3593

UniProt

P29460

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human IL12 p40

Clonality

Monoclonal

Clone

Clone: 24I67

Tissue Specificity

Expressed in brain and skeletal muscle. .

Applications

WB

Field of Research

Cancer, Cardiovascular, Hypertrophy, Protein Phosphorylation, Ser/Thr Kinases, Serine/Threonine Kinases, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

35609 MW

Observed Molecular Weight

40 kDa

Applications Notes

WB 1:500-1:2000

Gene Name Synonym

NF-kappa-B inhibitor alpha

Subcellular Location

Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. .

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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