Anti-PRKRA Rabbit Monoclonal Antibody

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621) . Specifically recognizes and binds N6- methyladenosine (m6A) -containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non- coding RNAs (lncRNAs) via a mechanism named 'm (6) A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671) . Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre- mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'- UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621) . .