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Anti-TIMM50 Rabbit Monoclonal Antibody

Boster Bio Anti-TIMM50 Rabbit Monoclonal Antibody catalog # M10056-1. Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Cysteine protease ATG4C;3.4.22.-; AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; ATG4C; APG4C, AUTL1, AUTL3

Gene Name

TIMM50

Gene ID

92609

UniProt

Q3ZCQ8

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A synthesized peptide derived from human TIMM50

Clonality

Monoclonal

Clone

Clone: 22T54

Tissue Specificity

Highly expressed in skeletal muscle, heart, liver and testis. .

Applications

WB, IHC

Field of Research

Metabolism Processes, Oncoproteins, Oncoproteins/Suppressors, Pathways and Processes, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity) . Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

52497 MW

Observed Molecular Weight

36 kDa

Gene Name Synonym

Cysteine protease ATG4C

Subcellular Location

Cytoplasm .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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