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Anti-PICK1 Rabbit Monoclonal Antibody

Selected Variant

M02457-1

Size: 100 µL/Vial

Boster Bio Anti-PICK1 Rabbit Monoclonal Antibody catalog # M02457-1. Tested in WB, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Major prion protein; PrP; ASCR; PrP27-30; PrP33-35C; CD230; PRNP; ALTPRP, PRIP, PRP

Gene Name

PICK1

Gene ID

9463

UniProt

Q9NRD5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human PICK1

Clonality

Monoclonal

Clone

Clone: 19P66

Tissue Specificity

Ubiquitous.

Applications

WB, IP, Flow Cytometry

Field of Research

Hematopoietic Progenitors, Neurodegenerative Disease, Neurology Process, Neuroscience, Stem Cells, Surface Molecules

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) . Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu (2+) or ZN (2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

27661 MW

Observed Molecular Weight

50 kDa

Gene Name Synonym

Major prion protein

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of CU (2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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