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Anti-LIS1 Rabbit Monoclonal Antibody

Boster Bio Anti-LIS1 Rabbit Monoclonal Antibody catalog # M01273. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Glutaminase kidney isoform, mitochondrial; GLS;3.5.1.2; K-glutaminase; L-glutamine amidohydrolase; GLS; GLS1, KIAA0838

Gene Name

PAFAH1B1

Gene ID

5048

UniProt

P43034

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human LIS1

Clonality

Monoclonal

Clone

Clone: 19P48

Tissue Specificity

Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and pancreas, detected at lower levels in placenta, lung, pancreas and kidney, but is not detected in liver. Isoform 2 is expressed in cardiac and skeletal muscle. .

Applications

WB

Field of Research

Amino Acid Metabolism, Amino Acids, Cancer, Metabolic Signaling Pathways, Metabolism, Mitochondria, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Organelles, Pathways and Processes, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

73461 MW

Observed Molecular Weight

70 kDa

Gene Name Synonym

Glutaminase kidney isoform, mitochondrial

Subcellular Location

Isoform 1: Cytoplasm, cytosol.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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