Anti-Nck NCK1 Monoclonal Antibody
Boster Bio Anti-Nck NCK1 Monoclonal Antibody catalog # M02260. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Oligodendrocyte transcription factor 2; Oligo2; Class B basic helix-loop-helix protein 1; bHLHb1; Class E basic helix-loop-helix protein 19; bHLHe19; Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17; OLIG2; BHLHB1, BHLHE19, PRKCBP2, RACK17
Gene Name
NCK1
Gene ID
4690
UniProt
P16333
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human Nck Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1.
Clonality
Monoclonal
Clone
Clone: AFEG-14
Tissue Specificity
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. .
Applications
WB, IHC, ICC, IF, IP, Flow Cytometry
Field of Research
Actin Assembly, Actin, etc., Adapters, Cancer, Cancer Susceptibility, Cytoplasmic, Cytoskeleton, Cytoskeleton/ECM, Epigenetics and Nuclear Signaling, Microfilaments, Oncoproteins, Oncoproteins/Suppressors, Proto-Oncogenes, Signal Transduction, Transcription
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity) . .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
32385 MW
Observed Molecular Weight
16 kDa
Gene Name Synonym
Oligodendrocyte transcription factor 2
Subcellular Location
Nucleus . Cytoplasm . The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. .
Protein Name
Lysosome-associated membrane glycoprotein 2 (Lamp2)
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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