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Anti-NR0B1 / DAX1 Monoclonal Antibody

Boster Bio Anti-NR0B1 / DAX1 Monoclonal Antibody catalog # M01521. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.

Product Specifications

Synonyms

Macrophage metalloelastase; MME;3.4.24.65; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12; MMP12; HME

Gene Name

NR0B1

Gene ID

190

UniProt

P51843

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human NR0B1 / Dax1 Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions.

Clonality

Monoclonal

Clone

Clone: AECC-14

Tissue Specificity

Found in alveolar macrophages but not in peripheral blood monocytes.

Applications

WB, IHC, ICC, IF, Flow Cytometry

Field of Research

Developmental Biology, Endocrine System, Epigenetics and Nuclear Signaling, Neuroscience, Nuclear Receptors, Nuclear Signaling Pathways, Reproduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

54002 MW

Observed Molecular Weight

43 kDa

Gene Name Synonym

Macrophage metalloelastase

Subcellular Location

Secreted, extracellular space, extracellular matrix .

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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