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Anti-SAE2 / UBA2 Monoclonal Antibody

Boster Bio Anti-SAE2 / UBA2 Monoclonal Antibody catalog # M03816. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Protein disulfide-isomerase A6;5.3.4.1; Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7; PDIA6; ERP5, P5, TXNDC7

Gene Name

UBA2

Gene ID

10054

UniProt

Q9UBT2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human SAE2 / UBA2 The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Clonality

Monoclonal

Clone

Clone: AEAI-21

Tissue Specificity

Expressed in platelets (at protein level) . .

Applications

WB, IHC, ICC, IF, IP

Field of Research

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

48121 MW

Observed Molecular Weight

43 kDa

Gene Name Synonym

Protein disulfide-isomerase A6

Subcellular Location

Endoplasmic reticulum lumen . Cell membrane . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545) . .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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