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Anti-Pyruvate Dehydrogenase E1 beta subunit PDHB Monoclonal Antibody

Boster Bio Anti-Pyruvate Dehydrogenase E1 beta subunit PDHB Monoclonal Antibody catalog # M03998. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPKK 5;2.7.12.2; MAPK/ERK kinase 5; MEK 5; MAP2K5; MEK5, MKK5, PRKMK5

Gene Name

PDHB

Gene ID

5162

UniProt

P11177

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Pyruvate Dehydrogenase E1 beta subunit The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO (2) . It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) .

Clonality

Monoclonal

Clone

Clone: AEAD-16

Tissue Specificity

Expressed in many adult tissues. Abundant in heart and skeletal muscle.

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

Cancer, Cardiogenesis, Cardiovascular, MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Serine/Threonine Kinases, Signal Transduction, Transcription Factors/Regulators

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

35 kDa

Observed Molecular Weight

35 kDa

Gene Name Synonym

Dual specificity mitogen-activated protein kinase kinase 5

Subcellular Location

Cytoplasm, cytoskeleton . Cell projection, lamellipodium . At the interface between the lamellipodial actin meshwork and the membrane. .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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