Anti-DNA Ligase IV Rabbit Monoclonal Antibody
Boster Bio Anti-DNA Ligase IV Rabbit Monoclonal Antibody catalog # M01685. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.
Product Specifications
Synonyms
Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD146; MCAM; MUC18
Gene Name
LIG4
Gene ID
3981
UniProt
P49917
Host
Rabbit
Reactivity
Human
Immunogen
A synthesized peptide derived from human DNA Ligase IV
Clonality
Monoclonal
Clone
Clone: ADHG-12
Tissue Specificity
Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.
Applications
WB, IHC, ICC, IF
Field of Research
Cancer, Cell Adhesion, Cell Adhesion Molecules, Cell Type Markers, Cytoskeleton/ECM, Immunology, Invasion/Microenvironment, Signal Transduction, Stem Cells
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
71607 MW
Observed Molecular Weight
120 kDa
Gene Name Synonym
Cell surface glycoprotein MUC18
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
Lysosome-associated membrane glycoprotein 2 (Lamp2)
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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