Anti-SMYD3 Monoclonal Antibody
Boster Bio Anti-SMYD3 Monoclonal Antibody catalog # M02080. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Junctional adhesion molecule A; JAM-A; Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD321; F11R; JAM1, JCAM; UNQ264/PRO301
Gene Name
SMYD3
Gene ID
64754
UniProt
Q9H7B4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human SMYD3 Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.
Clonality
Monoclonal
Clone
Clone: ADHE-19
Tissue Specificity
Predominantly in urogenital tissues.
Applications
WB, IHC, ICC, IF, IP, Flow Cytometry
Field of Research
Cancer, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Methylation, Oncoproteins, Oncoproteins/Suppressors, Pol II Transcription, Polymerase Associated Factors, Transcription, Transcription Factors
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity) . Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
32583 MW
Observed Molecular Weight
29 kDa
Gene Name Synonym
Junctional adhesion molecule A
Subcellular Location
Cell junction, tight junction . Cell membrane ; Single-pass type I membrane protein . Localized at tight junctions of both epithelial and endothelial cells.
Protein Name
Lysosome-associated membrane glycoprotein 2 (Lamp2)
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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