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Anti-GRB2 Monoclonal Antibody

Boster Bio Anti-GRB2 Monoclonal Antibody catalog # M00351. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295; LEPR; DB, OBR

Gene Name

GRB2

Gene ID

2885

UniProt

P62993

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human GRB2 Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

Clonality

Monoclonal

Clone

Clone: ADGO-7

Tissue Specificity

Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.

Applications

WB, IHC, ICC, IF, IP

Field of Research

Adapters, Cancer, Cytoplasmic, G Protein Signaling, Ras Family, Signal Transduction, Small G Proteins

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Receptor for obesity factor (leptin) . On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

132494 MW

Observed Molecular Weight

23 kDa

Gene Name Synonym

Leptin receptor

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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