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Anti-Securin Monoclonal Antibody

Boster Bio Anti-Securin Monoclonal Antibody catalog # M02099. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human.

Product Specifications

Synonyms

Actin-related protein 2/3 complex subunit 5; Arp2/3 complex 16 kDa subunit; p16-ARC; ARPC5; ARC16

Gene Name

PTTG1

Gene ID

9232

UniProt

O95997

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Securin Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes.

Clonality

Monoclonal

Clone

Clone: ADFH-16

Tissue Specificity

Predominantly in urogenital tissues.

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

Cancer, Epigenetics and Nuclear Signaling, Nuclear Import/Export, Protein Trafficking, Signal Transduction, Transcription, Tumor Biomarkers

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

16320 MW

Observed Molecular Weight

26 kDa

Gene Name Synonym

Actin-related protein 2/3 complex subunit 5

Subcellular Location

Cytoplasm, cytoskeleton . Cell projection .

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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