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Anti-macroH2A.1 H2AFY Monoclonal Antibody

Boster Bio Anti-macroH2A.1 H2AFY Monoclonal Antibody catalog # M04635. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Glycine--tRNA ligase;3.6.1.17 ;6.1.1.14 ; Diadenosine tetraphosphate synthetase; AP-4-A synthetase; Glycyl-tRNA synthetase; GlyRS; GARS

Gene Name

H2AFY

Gene ID

9555

UniProt

O75367

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human macroH2A.1 Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces an hypoacetylated state of chromatin.

Clonality

Monoclonal

Clone

Clone: ADDI-8

Tissue Specificity

Widely expressed, including brain and spinal cord. .

Applications

WB, IHC, ICC, IF

Field of Research

Epigenetics and Nuclear Signaling,2339, Histones

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Catalyzes the attachment of glycine to tRNA (Gly) . Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by condensation of 2 ATPs. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

83166 MW

Observed Molecular Weight

38 kDa

Gene Name Synonym

Glycine--tRNA ligase

Subcellular Location

Cytoplasm . Mitochondrion . Cell projection, axon . Associated with granules in cultured neuron cells. .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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