Anti-TAX1BP3 Monoclonal Antibody

A synthesized peptide derived from human TAX1BP3 May play a role in the Rho signaling pathway. May act as an inhibitor of the Wnt signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.

Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level) . .

Cytoplasmic, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, G Protein Signaling, Nuclear, Regulators, Signal Transduction, Signaling Pathway, Signaling Pathways, Small G Proteins, Stem Cells, Transcription

Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. .

Cytoplasm . Cytoplasm, cell cortex . Cell junction . Cell projection . Cell projection, growth cone . In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400) . Colocalized with DBN1, RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity) . .