Anti-USP28 Monoclonal Antibody
Boster Bio Anti-USP28 Monoclonal Antibody catalog # M05040. Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.
Product Specifications
Synonyms
Polypyrimidine tract-binding protein 2; Neural polypyrimidine tract-binding protein; Neurally-enriched homolog of PTB; PTB-like protein; PTBP2; NPTB, PTB, PTBLP
Gene Name
USP28
Gene ID
57646
UniProt
Q96RU2
Host
Rabbit
Reactivity
Human
Immunogen
A synthesized peptide derived from human USP28 Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN.
Clonality
Monoclonal
Clone
Clone: ADDO-21
Tissue Specificity
Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non- neuronal tissues. .
Applications
WB, ICC, IF, Flow Cytometry
Field of Research
Apoptosis, Cancer, Cell Biology, Cell Death, Deubiquitination, Epigenetics and Nuclear Signaling, Invasion/Microenvironment, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin & Ubiquitin Like Modifiers
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
57491 MW
Observed Molecular Weight
100 kDa
Gene Name Synonym
Polypyrimidine tract-binding protein 2
Subcellular Location
Nucleus .
Protein Name
T-cell surface glycoprotein CD3 zeta chain
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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