Anti-IKB epsilon NFKBIE Monoclonal Antibody
Boster Bio Anti-IKB epsilon NFKBIE Monoclonal Antibody catalog # M07073. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human.
Product Specifications
Synonyms
MAD2L1-binding protein; Caught by MAD2 protein; MAD2L1BP; CMT2, KIAA0110
Gene Name
NFKBIE
Gene ID
4794
UniProt
O00221
Host
Rabbit
Reactivity
Human
Immunogen
A synthesized peptide derived from human IKB epsilon Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
Clonality
Monoclonal
Clone
Clone: ADCF-14
Tissue Specificity
Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level) . Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate. .
Applications
WB, IHC, ICC, IF, IP
Field of Research
Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, NFKB Pathway, Nuclear Signaling, Signal Transduction, Signaling Pathway, TLR Signaling, Transcription, Transcription Factors
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
31052 MW
Observed Molecular Weight
116 kDa
Gene Name Synonym
MAD2L1-binding protein
Subcellular Location
Nucleus. Cytoplasm, cytoskeleton, spindle. During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
Protein Name
T-cell surface glycoprotein CD3 zeta chain
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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