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Anti-MCM7 Monoclonal Antibody

Boster Bio Anti-MCM7 Monoclonal Antibody catalog # M01649-1. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Mucin-16 ; MUC-16; Ovarian cancer-related tumor marker CA125 ; CA-125 ; Ovarian carcinoma antigen CA125 ; MUC16 ; CA125

Gene Name

MCM7

Gene ID

4176

UniProt

P33993

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human MCM7 Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.

Clonality

Monoclonal

Clone

Clone: BA-13

Tissue Specificity

Expressed in corneal and conjunctival epithelia (at protein level) . Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. .

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

1519175 MW

Observed Molecular Weight

79 kDa

Gene Name Synonym

Mucin-16

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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