Anti-Cytochrome P450 3A4 CYP3A4 Monoclonal Antibody
Boster Bio Anti-Cytochrome P450 3A4 CYP3A4 Monoclonal Antibody catalog # M00339. Tested in WB, IHC, IP applications. This antibody reacts with Human.
Product Specifications
Synonyms
Bone morphogenetic protein 2; BMP-2; Bone morphogenetic protein 2A; BMP-2A; BMP2; BMP2A
Gene Name
CYP3A4
Gene ID
1576
UniProt
P08684
Host
Rabbit
Reactivity
Human
Immunogen
A synthesized peptide derived from human Cytochrome P450 3A4 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.
Clonality
Monoclonal
Clone
Clone: ACDE-3
Tissue Specificity
Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Applications
WB, IHC, IP
Field of Research
Cardiovascular, Cytochromes, Growth Factors/Hormones, Lipases, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
Induces cartilage and bone formation (PubMed:3201241) . Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451) . .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
44702 MW
Observed Molecular Weight
32 kDa
Gene Name Synonym
Bone morphogenetic protein 2
Subcellular Location
Secreted.
Protein Name
P2X purinoceptor 1
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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