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Anti-SERPINC1 Monoclonal Antibody

Boster Bio Anti-SERPINC1 Monoclonal Antibody catalog # M00469. Tested in WB, ICC/IF applications. This antibody reacts with Human.

Product Specifications

Synonyms

Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD49d; ITGA4; CD49D

Gene Name

SERPINC1

Gene ID

462

UniProt

P01008

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human SERPINC1 Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Clonality

Monoclonal

Clone

Clone: ACCA-19

Tissue Specificity

Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.

Applications

WB, ICC, IF

Field of Research

Cardiovascular, Cell Biology, Protease Inhibitors, Proteolysis/Ubiquitin

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

114900 MW

Observed Molecular Weight

24 kDa, 29 kDa

Gene Name Synonym

Integrin alpha-4

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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