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Anti-PDK1 Monoclonal Antibody

Boster Bio Anti-PDK1 Monoclonal Antibody catalog # M01268. Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Actin, cytoplasmic 1; Beta-actin; Actin, cytoplasmic 1, N-terminally processed; ACTB

Gene Name

PDK1

Gene ID

5163

UniProt

Q15118

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human PDK1 Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

Clonality

Monoclonal

Clone

Clone: ACOF-16

Tissue Specificity

Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas. Normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth.

Applications

WB, IP

Field of Research

Cancer, Cancer Metabolism, Carbohydrate Metabolism, Chromatin Modifying Enzymes, Energy Metabolism, Energy Transfer Pathways, Epigenetics and Nuclear Signaling, Integration Of Energy, Integration Of Energy Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Carbohydrates, Methylation, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Oncoproteins/Suppressors, Pathways and Processes, Signal Transduction, Tumor Suppressors

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

41737 MW

Observed Molecular Weight

42 kDa

Gene Name Synonym

Actin, cytoplasmic 1

Subcellular Location

Cytoplasm, cytoskeleton . Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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