Anti-67kDa Laminin Receptor RPSA Rabbit Monoclonal Antibody

40S ribosomal protein SA ;37 kDa laminin receptor precursor ;37LRP ;37/67 kDa laminin receptor ; LRP/LR ;67 kDa laminin receptor ;67LR ; Colon carcinoma laminin-binding protein; Laminin receptor 1 ; LamR ; Laminin-binding protein precursor p40 ; LBP/p40 ; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; RPSA ; LAMBR, LAMR1

Expressed in both pancreatic alpha- and beta- cells (at protein level) . Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood. .

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Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. .

Cell membrane. Cytoplasm. Nucleus . 67LR is found at the surface of the plasma membrane, with its C-terminal laminin- binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity) . Colocalizes with PPP1R16B in the cell membrane. .