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Anti-Cytokeratin 4 KRT4 Rabbit Monoclonal Antibody

Boster Bio Anti-Cytokeratin 4 KRT4 Rabbit Monoclonal Antibody catalog # M07410. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Rat.

Product Specifications

Synonyms

Keratin, type II cytoskeletal 4; Cytokeratin-4; CK-4; Keratin-4; K4; Type-II keratin Kb4; KRT4; CYK4

Gene Name

KRT4

Gene ID

3851

UniProt

P19013

Host

Rabbit

Reactivity

Human, Rat

Immunogen

A synthesized peptide derived from human Cytokeratin 4

Clonality

Monoclonal

Clone

Clone: GFO-11

Tissue Specificity

Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level) . Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer. .

Applications

WB, IHC, ICC, IF

Field of Research

Cell Type Markers, Class I, Cytoskeleton, Cytoskeleton/ECM, Intermediate Filaments, Microtubules, Signal Transduction, Tags & Cell Markers

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

57285 MW

Observed Molecular Weight

47 kDa

Gene Name Synonym

Keratin, type II cytoskeletal 4

Subcellular Location

Nucleus. Chromosome.

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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