Anti-pro Caspase 3 CASP3 Rabbit Monoclonal Antibody
Boster Bio Anti-pro Caspase 3 CASP3 Rabbit Monoclonal Antibody catalog # M00334. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Caspase-3; CASP-3;3.4.22.56; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1; Caspase-3 subunit p17; Caspase-3 subunit p12; CASP3; CPP32
Gene Name
CASP3
Gene ID
836
UniProt
P42574
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthesized peptide derived from human pro Caspase 3
Clonality
Monoclonal
Clone
Clone: AOB-3
Tissue Specificity
Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Applications
WB, IHC, ICC, IF, IP, Flow Cytometry
Field of Research
Alzheimer's Disease, Apoptosis, Apoptotic Markers, Cancer, Caspases, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Neurodegenerative Disease, Neurology Process, Neuroscience
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
31608 MW
Observed Molecular Weight
47 kDa
Gene Name Synonym
Caspase-3
Subcellular Location
Cytoplasm.
Protein Name
P2X purinoceptor 1
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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