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Anti-Neuropilin 1 NRP1 Rabbit Monoclonal Antibody

Boster Bio Anti-Neuropilin 1 NRP1 Rabbit Monoclonal Antibody catalog # M01324. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; CD304; NRP1; NRP, VEGF165R

Gene Name

NRP1

Gene ID

8829

UniProt

O14786

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Neuropilin 1

Clonality

Monoclonal

Clone

Clone: BGO-14

Tissue Specificity

The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

Adaptive Immunity, Angiogenesis, Axonal Guidance Proteins, Cardiovascular, Growth and Development, Growth Factors, Immunology, Neurology Process, Neuroscience

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

103134 MW

Observed Molecular Weight

38-42 kDa

Gene Name Synonym

Neuropilin-1

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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