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Anti-Cdc27/APC3 Rabbit Monoclonal Antibody

Boster Bio Anti-Cdc27/APC3 Rabbit Monoclonal Antibody catalog # M03905. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Cell division cycle protein 27 homolog; Anaphase-promoting complex subunit 3; APC3; CDC27 homolog; CDC27Hs; H-NUC; CDC27; ANAPC3, D0S1430E, D17S978E

Gene Name

CDC27

Gene ID

996

UniProt

P30260

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Cdc27/APC3

Clonality

Monoclonal

Clone

Clone: IOB-3

Tissue Specificity

Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. .

Applications

WB

Field of Research

Cell Biology, Cell Cycle, Cell Division, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Spindle

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

91867 MW

Observed Molecular Weight

35 kDa

Gene Name Synonym

Cell division cycle protein 27 homolog

Subcellular Location

Nucleus.

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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