Anti-HIF-1 beta ARNT Rabbit Monoclonal Antibody
Boster Bio Anti-HIF-1 beta ARNT Rabbit Monoclonal Antibody catalog # M02263. Tested in WB, IHC applications. This antibody reacts with Human.
Product Specifications
Synonyms
Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta; ARNT; BHLHE2
Gene Name
ARNT
Gene ID
405
UniProt
P27540
Host
Rabbit
Reactivity
Human
Immunogen
A synthesized peptide derived from human HIF-1 beta
Clonality
Monoclonal
Clone
Clone: EAD-1
Tissue Specificity
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. .
Applications
WB, IHC
Field of Research
Cancer, Cancer Metabolism, Epigenetics and Nuclear Signaling, Metabolism, Metabolism Processes, Neural Signal Transduction, Neurology Process, Neuroscience, Pathways and Processes, Pol II Transcription, Polymerase Associated Factors, Response To Hypoxia, Transcription, Transcription Factors
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
86636 MW
Observed Molecular Weight
16 kDa
Gene Name Synonym
Aryl hydrocarbon receptor nuclear translocator
Subcellular Location
Nucleus.
Protein Name
Lysosome-associated membrane glycoprotein 2 (Lamp2)
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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