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Anti-HP1 alpha CBX5 Rabbit Monoclonal Antibody

Boster Bio Anti-HP1 alpha CBX5 Rabbit Monoclonal Antibody catalog # M02780. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha; CBX5; HP1A

Gene Name

CBX5

Gene ID

23468

UniProt

P45973

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human HP1 alpha

Clonality

Monoclonal

Clone

Clone: DHO-3

Tissue Specificity

Widely expressed.

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

2339, Chromatin Binding Proteins, Epigenetics and Nuclear Signaling, Nucleus, Subcellular Markers, Tags & Cell Markers

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) . Can interact with lamin-B receptor (LBR) . This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

22225 MW

Observed Molecular Weight

70 kDa, 90 kDa

Gene Name Synonym

Chromobox protein homolog 5

Subcellular Location

Nucleus . Chromosome . Chromosome, centromere . Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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