Anti-Drebrin DBN1 Rabbit Monoclonal Antibody
Boster Bio Anti-Drebrin DBN1 Rabbit Monoclonal Antibody catalog # M05530. Tested in WB, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Drebrin; Developmentally-regulated brain protein; DBN1; D0S117E
Gene Name
DBN1
Gene ID
1627
UniProt
Q16643
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human Drebrin
Clonality
Monoclonal
Clone
Clone: ABDC-4
Tissue Specificity
Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level) . .
Applications
WB, ICC, IF, IP
Field of Research
ECM Proteins, Invasion/Microenvironment, Microfilaments, Neurodegenerative Disease, Neurology Process, Neuron Marker, Neuroscience, Signal Transduction
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
71429 MW
Observed Molecular Weight
120 kDa
Gene Name Synonym
Drebrin
Subcellular Location
Cytoplasm . Cytoplasm, cell cortex . Cell junction . Cell projection . Cell projection, growth cone . In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400) . Colocalized with DBN1, RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity) . .
Protein Name
T-cell surface glycoprotein CD3 zeta chain
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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