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Anti-NOTCH4 Rabbit Monoclonal Antibody

Boster Bio Anti-NOTCH4 Rabbit Monoclonal Antibody catalog # M02582. Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Neurogenic locus notch homolog protein 4; Notch 4; hNotch4; Notch 4 extracellular truncation; Notch 4 intracellular domain; NOTCH4; INT3

Gene Name

NOTCH4

Gene ID

4855

UniProt

Q99466

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A synthesized peptide derived from human NOTCH4

Clonality

Monoclonal

Clone

Clone: IOC-14

Tissue Specificity

Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.

Applications

WB, Flow Cytometry

Field of Research

Cardiogenesis, Cardiovascular, Epigenetics and Nuclear Signaling, Nuclear, Signaling Pathways, Stem Cells, Surface Molecules, Transcription, Transcription Factors/Regulators

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

209622 MW

Observed Molecular Weight

41 kDa

Gene Name Synonym

Neurogenic locus notch homolog protein 4

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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