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Anti-EIF2C3 AGO3 Rabbit Monoclonal Antibody

Boster Bio Anti-EIF2C3 AGO3 Rabbit Monoclonal Antibody catalog # M04191. Tested in IHC, WB application. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Protein argonaute-3 ; Argonaute3 ; hAgo3; Argonaute RISC catalytic component 3; Eukaryotic translation initiation factor 2C 3 ; eIF-2C 3 ; eIF2C 3 ; AGO3; EIF2C3

Gene Name

AGO3

Gene ID

192669

UniProt

Q9H9G7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human EIF2C3

Clonality

Monoclonal

Clone

Clone: GGF-1

Tissue Specificity

Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. .

Applications

WB, IHC

Field of Research

DNA/RNA, Epigenetics and Nuclear Signaling, RNA Processing

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Required for RNA-mediated gene silencing (RNAi) . Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

97360 MW

Observed Molecular Weight

70 kDa

Gene Name Synonym

Protein argonaute-3

Subcellular Location

Cytoplasm, P-body .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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