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Anti-53BP1 TP53BP1 Rabbit Monoclonal Antibody

Boster Bio Anti-53BP1 TP53BP1 Rabbit Monoclonal Antibody catalog # M00397. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Tumor suppressor p53-binding protein 1;53BP1; p53-binding protein 1; p53BP1; TP53BP1

Gene Name

TP53BP1

Gene ID

7158

UniProt

Q12888

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human 53BP1

Clonality

Monoclonal

Clone

Clone: ABAI-20

Tissue Specificity

Released primarily from activated T lymphocytes.

Applications

WB, IHC, ICC, IF, Flow Cytometry

Field of Research

Cancer, DNA/RNA, DNA Damage & Repair, DNA Damage Response, Epigenetics and Nuclear Signaling, Oncoproteins/Suppressors, p53 Pathway, Tumor Suppressors

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

213574 MW

Observed Molecular Weight

450 kDa

Gene Name Synonym

Tumor suppressor p53-binding protein 1

Subcellular Location

Nucleus. Chromosome, centromere, kinetochore. Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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