Anti-RPE65 Rabbit Monoclonal Antibody
Boster Bio Anti-RPE65 Rabbit Monoclonal Antibody catalog # M00824. Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Retinoid isomerohydrolase;3.1.1.64; All-trans-retinyl-palmitate hydrolase; Retinal pigment epithelium-specific 65 kDa protein; Retinol isomerase; RPE65
Gene Name
RPE65
Gene ID
6121
UniProt
Q16518
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human RPE65
Clonality
Monoclonal
Clone
Clone: ABAH-18
Tissue Specificity
Retinal pigment epithelium specific. .
Applications
WB, IP
Field of Research
Cancer, Cell Type Markers, Cofactors, Vitamins/Minerals, Metabolism, Neuroscience, Pathways and Processes, Sensory System, Signal Transduction, Tags & Cell Markers, Visual System, Vitamins/Minerals
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
60948 MW
Observed Molecular Weight
95 kDa
Gene Name Synonym
Retinoid isomerohydrolase
Subcellular Location
Cytoplasm . Cell membrane ; Lipid-anchor . Microsome membrane . Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated (By similarity) . Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells. .
Protein Name
Glycogen synthase kinase-3 beta (gsk3b)
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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