Anti-GATA4 Rabbit Monoclonal Antibody

Cancer, Cardiovascular, Developmental Biology, Domain Families, Epigenetics and Nuclear Signaling, Hypertrophy, Lineage Markers, Lineage Specification, Mesenchymal Stem Cells, Oncoproteins/Suppressors, Stem Cells, Transcription, Transcription Factors, Tumor Suppressors, Zinc Finger

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed:24000169) . Involved in bone morphogenetic protein (BMP) - mediated induction of cardiac-specific gene expression (By similarity) . Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity) . Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity) . Promotes cardiac myocyte enlargement (PubMed:20081228) . Required during testicular development (PubMed:21220346) . May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735) . .