Anti-NFAT1 NFATC2 Rabbit Monoclonal Antibody
Boster Bio Anti-NFAT1 NFATC2 Rabbit Monoclonal Antibody catalog # M00969. Tested in WB application. This antibody reacts with Human.
Product Specifications
Synonyms
Nuclear factor of activated T-cells, cytoplasmic 2; NF-ATc2; NFATc2; NFAT pre-existing subunit; NF-ATp; T-cell transcription factor NFAT1; NFATC2; NFAT1, NFATP
Gene Name
NFATC2
Gene ID
4773
UniProt
Q13469
Host
Rabbit
Reactivity
Human
Immunogen
A synthesized peptide derived from human NFAT1
Clonality
Monoclonal
Clone
Clone: AAFG-14
Tissue Specificity
Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highly expressed in stomach, uterus, placenta, trachea and thyroid. .
Applications
WB
Field of Research
Adaptive Immunity, Cytokines, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
100146 MW
Observed Molecular Weight
150 kDa
Gene Name Synonym
Nuclear factor of activated T-cells, cytoplasmic 2
Subcellular Location
Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Protein Name
Glycogen synthase kinase-3 beta (gsk3b)
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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