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Anti-ASPP2 Rabbit Monoclonal Antibody

Boster Bio Anti-ASPP2 Rabbit Monoclonal Antibody catalog # M02609. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

Product Specifications

Synonyms

Apoptosis-stimulating of p53 protein 2; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2;53BP2; p53-binding protein 2; p53BP2; TP53BP2; ASPP2, BBP

Gene Name

TP53BP2

Gene ID

7159

UniProt

Q13625

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human ASPP2

Clonality

Monoclonal

Clone

Clone: AOEA-20

Tissue Specificity

Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines. .

Applications

WB, IHC, ICC, IF

Field of Research

Cell Biology, Cell Cycle, Cell Cycle Inhibitors

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

125616 MW

Observed Molecular Weight

45 kDa

Gene Name Synonym

Apoptosis-stimulating of p53 protein 2

Subcellular Location

Cytoplasm, perinuclear region. Nucleus. Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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