Anti-VAMP8/Endobrevin Rabbit Monoclonal Antibody

Cell Type Marker, Immunology, Innate Immunity, Macrophage/Inflammation, Neuron Marker, Neuroscience, Neurotransmission, Secretory Vesicles, Synapse Marker

SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604) . Also required for dense-granule secretion in platelets (PubMed:12130530) . Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity) . Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity) . Involved in the homotypic fusion of early and late endosomes (By similarity) . .

Lysosome membrane ; Single-pass type IV membrane protein . Early endosome membrane ; Single-pass type IV membrane protein . Late endosome membrane ; Single-pass type IV membrane protein . Cell membrane ; Single-pass type IV membrane protein . Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (By similarity) . Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell (By similarity) . Cycles through the apical but not through the basolateral plasma membrane (By similarity) . Apical region of acinar cells; in zymogen granule membranes (By similarity) . .