Anti-TIMP1 Rabbit Monoclonal Antibody
Boster Bio Anti-TIMP1 Rabbit Monoclonal Antibody catalog # M00561-1. Tested in WB, IHC applications. This antibody reacts with Human.
Product Specifications
Synonyms
Metalloproteinase inhibitor 1; Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1; TIMP1; CLGI, TIMP
Gene Name
TIMP1
Gene ID
7076
UniProt
P01033
Host
Rabbit
Reactivity
Human
Immunogen
A synthesized peptide derived from human TIMP1
Clonality
Monoclonal
Clone
Clone: AOOI-20
Tissue Specificity
Detected in rheumatoid synovial fluid (at protein level) . .
Applications
WB, IHC
Field of Research
Angiogenesis, Cancer, Cardiovascular, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Protease Inhibitors, Proteolysis/Ubiquitin, Signal Transduction
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
23171 MW
Observed Molecular Weight
17 kDa
Gene Name Synonym
Metalloproteinase inhibitor 1
Subcellular Location
Secreted .
Protein Name
T-cell surface glycoprotein CD4
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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