Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-CD146 MCAM Rabbit Monoclonal Antibody

Boster Bio Anti-CD146 MCAM Rabbit Monoclonal Antibody catalog # M01683-1. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD146; MCAM; MUC18

Gene Name

MCAM

Gene ID

4162

UniProt

P43121

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human CD146

Clonality

Monoclonal

Clone

Clone: AbC83

Tissue Specificity

Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

Cancer, Cell Adhesion, Cell Adhesion Molecules, Cell Type Markers, Cytoskeleton/ECM, Immunology, Invasion/Microenvironment, Signal Transduction, Stem Cells

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

71607 MW

Observed Molecular Weight

120 kDa

Gene Name Synonym

Cell surface glycoprotein MUC18

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Prolyl Hydroxylase 4, beta (P4HB, Cellular thyroid hormone-binding protein, DSI, ERBA2L, GIT, P4Hbeta, p55, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB, Prolyl 4-hydroxylase subunit beta, Protein disulfide-isomerase) (HRP) discontinued
P9018-30-HRP 100 µL

Prolyl Hydroxylase 4, beta (P4HB, Cellular thyroid hormone-binding protein, DSI, ERBA2L, GIT, P4Hbeta, p55, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB, Prolyl 4-hydroxylase subunit beta, Protein disulfide-isomerase) (HRP) discontinued

Ask
View Details
N-Nitroso Selumetinib-d4
TRC-N254001-75MG 75 mg

N-Nitroso Selumetinib-d4

Ask
View Details
Hamster Glycoprotein IIb/IIIa ELISA Kit
MBS073096-01 48 Well

Hamster Glycoprotein IIb/IIIa ELISA Kit

Ask
View Details
Hamster Glycoprotein IIb/IIIa ELISA Kit
MBS073096-02 96 Well

Hamster Glycoprotein IIb/IIIa ELISA Kit

Ask
View Details
Hamster Glycoprotein IIb/IIIa ELISA Kit
MBS073096-03 5x 96 Well

Hamster Glycoprotein IIb/IIIa ELISA Kit

Ask
View Details
Hamster Glycoprotein IIb/IIIa ELISA Kit
MBS073096-04 10x 96 Well

Hamster Glycoprotein IIb/IIIa ELISA Kit

Ask
View Details