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Anti-TLR9 Rabbit Monoclonal Antibody

Boster Bio Anti-TLR9 Rabbit Monoclonal Antibody catalog # M00198. Tested in WB application. This antibody reacts with Human.

Product Specifications

Synonyms

Toll-like receptor 9; CD289; TLR9; UNQ5798/PRO19605

Gene Name

TLR9

Gene ID

54106

UniProt

Q9NR96

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human TLR9

Clonality

Monoclonal

Clone

Clone: ABFH-20

Tissue Specificity

Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Applications

WB

Field of Research

Adapters, Immunoglobulins, Immunology, Innate Immunity, Macrophage/Inflammation, Receptors, Signal Transduction, TLR Signaling, Transmembrane

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

115860 MW

Observed Molecular Weight

103 kDa

Gene Name Synonym

Toll-like receptor 9

Subcellular Location

Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endosome . Lysosome . Cytoplasmic vesicle, phagosome . Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. .

Protein Name

P2X purinoceptor 1

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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