Anti-XBP1 Rabbit Monoclonal Antibody

X-box-binding protein 1 ; XBP-1 ; Tax-responsive element-binding protein 5 ; TREB-5 ; X-box-binding protein 1, cytoplasmic form ; X-box-binding protein 1, luminal form ; XBP1 ; TREB5 , XBP2

Expressed in plasma cells in rheumatoid synovium (PubMed:11460154) . Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941) . Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856) . .

Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR) . Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity) . Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154) . Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923) . Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596) . Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity) . .

Endoplasmic reticulum . Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF) -dependent manner (PubMed:23529610) . .