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Anti-M6PR IGF2R Rabbit Monoclonal Antibody

Boster Bio Anti-M6PR IGF2R Rabbit Monoclonal Antibody catalog # M00951. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR;300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD222; IGF2R; MPRI

Gene Name

IGF2R

Gene ID

3482

UniProt

P11717

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human M6PR

Clonality

Monoclonal

Clone

Clone: DIC-9

Tissue Specificity

Expressed in the excretory system, thyroid gland and Wilms tumors.

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

Signal Transduction, Subcellular Markers

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

274375 MW

Observed Molecular Weight

28 kDa

Gene Name Synonym

Cation-independent mannose-6-phosphate receptor

Subcellular Location

Lysosome membrane ; Single-pass type I membrane protein . Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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